Dr. Tan and Partners is one of the few approved Anonymous HIV Testing Centres in Singapore. A detailed write up on our service is available here.

Other STD services: Early STD Screening, Rapid Hepatitis B Blood Test, Swab for Gonorrhea and many more... contact us to make an appointment now!

HIV 4th Generation Test Singapore

The HIV 4th Generation Test is one of the most accurate and fastest way to determine is a person has been infected with HIV or not.

The HIV 4th Generation Test is also called the Combo test or the Duo test.

It tests for both the HIV antibodies as well as the antigens in the blood. It can be done as a rapid test i.e. you can get the results in 20 minutes.

Antibodies are produced by the body when it is infected with the HIV virus. There are many different types of antibodies. The one that is produced the earliest is called the IgM antibody. This can be produced as early as 20 days post exposure. 3rd and 4th Generation HIV tests can detect the IgM antibody.

Antigens are bits of the HIV virus shell that can be found in the blood as early as 14 days post exposure. The 4th Generation test can detect the presence of this antigen.

If the test detects either the presence of HIV antibodies or antigens, it means the patient is most likely infected with HIV. This has to be confirmed with another ELISA test. We always do at least 2 tests before diagnosing a person as HIV +ve.

Officially it is conclusive at 28 days post exposure. However, from current scientific data, we know that when the test is done at 20 days post exposure, it is already as good as 100% accurate. Personally I have tested patients +ve for HIV at only 14 days post exposure with this test.

The US CDC recommends the HIV 4th Generation test for all HIV screening. This is because it is more accurate, has a shorter window period and can pick up rare cases of sero-negative infections (see below).

The HIV 4th Generation test can detect HIV infections in very rare cases of people who are infected with HIV but never produce any anti-bodies. These are called sero-negative infections and happen in about 1 in 1 million people.

At our clinics the HIV 4th Generation test costs $150 (before GST).

You can walk in our clinics at Robertson Walk, Bencoolen Street, Novena Medical Center or Scotts Road anytime during our opening hours for this test. It only requires a finger-prick of blood and 20 minutes to get results.


We are Open on Saturdays and Sundays.

Click Here for Contact Details, Address and Opening Times.

Feel free to email your queries, feedback and suggestions on what other topics you want to see in the comments section below.


Click here for HIV Testing FAQ

More on HIV symptoms.

If you have any questions, visit our free online forum on sexual health, HIV and STDs.

Click here for Info on STD Symptoms in Men
Click here for Info on STD Symptoms in Women
Click here to see the full range of our HIV/STD Services

If you need a HIV test visit Our Clinics anytime during our opening hours. You do not need an appointment.


Find out more about Anonymous HIV testing at our clinics.

Can’t wait for 3 months to find out? Find out more about Anonymous Rapid HIV Combo test at our clinics.

If you had a high risk exposure to HIV within the past 72 hours, you can take medicines to reduce your risk of actually contracting HIV. Find out more on HIV PEP Treatment.


Related Topics:

Anonymous HIV testing at our Clinics

HIV – Understanding the Window Period

Cost of HIV/STD tests at our Clinics

Condom Broke

Getting HIV from Oral Sex

More on HIV symptoms

How long can HIV live outside the body?


We are Open on Saturdays and Sundays.

Click Here for Contact Details, Address and Opening Times.

Feel free to email your queries, feedback and suggestions on what other topics you want to see in the comments section below.


We are now Open on Weekends.

We have 5 locations conveniently located at Robertson Walk, Bencoolen Street, Novena, Scotts (Pacific Plaza) and Somerset (H&M)

Robertson Walk          6238 7810   map

Bencoolen Street        6884 4119   map

Novena                           6397 2095   map

Scotts                              6694 2348   map

Somerset                       6262 0762   map

Email: [email protected]

About Dr. Tan
Dr. Tan graduated from the National University of Singapore in 2001. His residency was in the two largest public hospitals in Singapore; Tan Tock Seng Hospital and Singapore General Hospital.

Find the profiles of our panel of doctors.


  1. Hello doctor
    I wrote a week ago so
    Here is my tests
    PCR RNA at day 11 negative
    4th generation DOU day 33 negative
    4th generation DOU day 43 negative

    How conclusive this results are percentage wise?

    Thank you

  2. Jackson

    Hi I had protected oral and vaginal sex with a sex worker on January but I took the gen 4 test 1 month after exposure and gen 3 test 3 month after exposure. Both came back negative but symptoms shows up after 6-7 months I have white smooths bump (2mm) lots of it appearing on my body some molloscum contagiosum and a cyst on my back became greyish black. I have severer acne on my back Long sag I also had diarreah past 2 weeks. No fever since exposure but flu keep coming and going. I also have acne near my neck due to this I am unsure weather it’s lymph nodes because the cystic acne is as big as the lymph node I’ve been stressing over this since the exposure. Also I feel tired easily. I fell like taking another test just to be sure. I’m uncircumcised and the foreskin can’t be pulled fully not even halfway. I just remembered she took of the condom and use lubricant to masterbate for me but I couldn’t cum. After I went back I masterbated myself till I cum. Is there a possibility in that?? Even though my test are negative my leg hurts as well now(7 months after exposure )

    • Your tests are conclusive, you most definitely do not have HIV and your symptoms are not from HIV. Please see a doctor for further evaluation if you are concerned.

      • Jackson

        I also have unexplain weight loss could Thian be
        Because of anxiety and stress. Because I just weigh and notice I have lost 3kg over the week was 71 last week and 68.5 now.

        • Jackson

          Not to mention I also notice a lot of mole appearing on my body from body hand to even the feet.

  3. Hi dr,

    Will hiv 2 pcr dna/rna qualitative test after 2 years eliminates all seronegative posibilities of hiv 2. I am sorry doctor i am worried a lot. Please answer me.


  4. Hi doctor
    I had a high risk of insertive unprotected anal sex with someone i dont know their status.

    I took RNA PCR test at day 11 Negative
    Due 4th generation at day 33 Negative

    I had no any symptoms

    I am very worried i cant live normally

    Please tell me what should i do next

    • Your tests are conclusive, you do not have HIV. You can move on with your life.

      • Hi doctor
        Two more questions

        1- i have 3.5 total WBC which is a bit low and it was always like this with 30% lymphocytes , could this affect the results in anyway?

        2- do i need to do any further testing?

        Thank you very much for your help.

  5. Hi Dr,

    I might have a possible risk 2 years back from oral sex in thailand. I have tested 2 times negative from hiv 4th gen test(hiv 1 and hiv 2). I am worried about seronegative case of “hiv 2”. Because for hiv-1 p24 antigen is already being tested but for hiv 2 there isn’t. So do i need to worry and proceed for hiv 2 rna testing. Both the hiv tests are done after 2 years.


    • Your initial risk from oral sex is close to zero. Your tests are conclusive. You are being paranoid over seronegative HIV-2 for absolutely no reason. Accept your results and move on with your life.

      • Thanks dr. You are helping us a lot. So I need not worry about the sensitivity of hiv 4th gen test for hiv 2

  6. Dear doctor,

    I have an abrasion on my penis as a result of masturbation. About 4 hrs later, i had oral sex (i’m the insertive partner) with someone who probably is HIV positive (his saliva touched the abrasion part). Is there a risk of HIV trasmission to me? Thank you

    • The risk is close to zero.

      • Hello Drs…
        I am a female And I had unprotected sex with two males. I had so many symptoms and I decided to take the HIV 1/2 4th at 100 dias with the first guy and 77 days with the second one. No reactive..
        how conclusive my resultas are or do I have to wait longer

  7. Hi Doc
    I am writing this from California, USA. I need to know few things:
    a) Is it possible for hiv to transmit from infected blood to my blood via lancet wound. I am taking about the wound or fingerprick opening caused by lancet while testing. I am asking this because I accidentally touched the container where the used blood syringes, cotton, blood swabs of patients were dumped. I am sure my finger touched one of the patient’s blood cotton.

    b) The above incident happened was on July 14th and I am thinking to get tested around July 20th which is I guess 33rd day from my exposure if i call that incident as my “last exposure”. So getting tested using Alere 4th gen HIV Combo test or some other 4th generation test will be conclusive at that time?

    • I am confident you will not get HIV in this manner. However, if you are still concerned and wish to test, then sure the 4th gen combo test will be conclusive from 28 days post-exposure onwards.

  8. Luis González

    Hi Doctor
    I performed oral sex to a girl that was on her menstrual period, after 8 weeks I experienced almost all early symptoms related to an hiv infection, at week 4 I tested negative in a 4th generation test and in week 8 I tested again negative in a 4th generation test, they advise my that to make 100% conclusive to test mi again at week 12, do you think that it can change from negative to positive in week 12? Tank you!

  9. Hi Dr,I would like to know is it 4th generation test conclusive at 28days?Because I taken the test on 29 days it shown non reactive but I still got body rash symptoms.

  10. Hi Dr, I’m confuse. I ask customer service, they said they using 4th gen Elisa hiv test. But they using CMIA method, if found abnormality, then only use Elisa method. So what they mean? Am I still using 4th gen Elisa test?

    • I cannot interpret what someone else tells you about their tests. You will need to clarify your doubts with them.

      • They mention they using 4th gen Elisa test, and using CMIA method. Are both same? Because they tell me they using 4th gen duo test. So if duo test, is the result conclusive after 28th days?

        • Hi Dr, confirm already, is using 4th gen CMIA test. I take the test at day 30th, result negative, can I said the result is conclusive and need not to repeat the test again? Or I need to retake the same test after 6 weeks?

          • It is conclusive.

          • hi doctor, last confirmation. I’m taking the test at BP lab Malaysia. On my report, they write HIV Ag/Ab screening (CMIA): non reactive. That all, so I can said the result is conclusive and need not repeat the test again right? Am I right? I’m taking the test again on day 48th.

          • It is conclusive.

          • The test is on day 48th

  11. Good day,

    I am 26 yr old male from manila i had 4th generation cmia test 48 days after receiving oral sex from a transgender result non reactive. Had rapid ict test 84 days after possible exposure result negative.can i consid r this test results conclusive?

    I hope to hear from you soon doctor.

  12. Dear doc,

    I had unprotected oral and protected (with latex condom) vaginal sex with a CSW.

    Did 4th Generation at 10 days mark. Negative. Schedule next test on 15 days and 30 days mark for 4th generation as well.

    What is my risk here? I’m so depressed with this stupid encounter.

    Need your advice.

    • Your risk is very low as long as the condom was used properly, but it is not zero risk. Just get yourself checked at the appropriate time.

      • Hi Doc,

        Oral was performed on me and condom didnt break nor slipped.

        Again, out of anxiety, I’m I at high risk. Didn’t notice bleeding mouth or sores on hers

        Is 4th Gen conclusive at 1 month mark?

  13. Hi docter! Hiv testing combo ag/ab ( architeck ) day 40 or week 6 ? Thanks Docter !

  14. Good Day Doctor,

    I am a male 26 yr old from Philippines. I took a 4th gen CMIA ab/ag test 48 days post exposure result non reactive. I just want to confirm if this is conclusive? And if i still have to re test?

  15. Hi Doctor,

    I am male 26 yr old from Philippines had a CMIA 4th generation test at 48 days possible exposure, should i consider this conclusive? Or should i take a re test at my 12th week?

    I hope to hear from you soon.

    Thank You.

    • I would consider your test conclusive, but please follow your local healthcare guidelines for confirmation.

      • Ok Doctor. Thank you for your quick response and understanding to us people with anxiety with this matter.

  16. Dear doctor,
    I`ve kissed a girl with a ulcers/sores in my mouth and I think that maybe also had ulcers/sores in mouth. I`ve made 2 elisa 4 generation, after 18 and 22 days. Can I consider my results conclusive?

    • Kissing is a zero risk activity so I would say your results are conclusive (and that you do not even need to do them in the first place).

      • Thanks doctor,

        I’ve read in some articles that as as saliva contains some enzymes that inactive the virus. Even if we both have ulcers/ sores In mouth the risk would be zero? Thanks again

  17. If I’m taking Luvox and apo-lorazepam from day 22th and take hiv test on day 33th, will it cause the test not accurate? Luvox 50mg per day and app-lorazepam 0.5mg per day.
    Day 14th, 24th, 33th, hiv test 4th gen result is negative.
    I’m quite nervous because about 4 weeks, I’m having diarrhea. Every times happen after meal. 3-4 times per day. Is the hiv test conclusive enough? Am I safe?
    Sorry to disturb but really need your comment.

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